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Published on 18 October 2010 By ESCP Secretariat In Genetics
Free paper - Francisco Lopez-Kostner at ESCP Sorrento 2010
Oral poster - Ashish Sinha at ESCP Sorrento 2010
Published on 15 October 2012 By ESCP Secretariat In Genetics
Oral poster - Min Hoe Chew at ESCP Vienna 2012
Oral poster - Yuri Chubarov at ESCP Vienna 2012
Published on 04 November 2013 By ESCP Secretariat In Genetics
Keynote lecture - Jean-Pierre Hugot at ESCP Belgrade 2013
Published on 07 August 2014 By ESCP Secretariat In Genetics
Short Paper - Reza Mirnezami (UK) at Tripartite Colorectal Meeting 2014
Short Paper - James Park (UK) at Tripartite Colorectal Meeting 2014
Published on 12 December 2014 By ESCP Secretariat In Genetics
Oral Poster (Neoplasia) - Mattias Prytz at ESCP Barcelona 2014
Symposium - Yann Parc at ESCP Barcelona 2014
Symposium - Graham Williams at ESCP Barcelona 2014
Published on 24 November 2015 By ESCP Secretariat In Genetics
Oral Poster (Neoplasia) - Gabriela Möslein at ESCP Dublin 2015
Published on 25 November 2015 By ESCP Secretariat In Genetics
Symposium - Jérémie Lefevre at ESCP Dublin 2015
Symposium - Gabriella Möslein at ESCP Dublin 2015
Symposium - Des Winter at ESCP Dublin 2015
Oral Poster (Functional) - Farouk Drissi at ESCP Dublin 2015
Published on 03 November 2016 By ESCP Secretariat In Genetics
Educational session - Paul Goldberg at ESCP Milan 2016
Keynote Lecture - Jan Paul Medema at ESCP Milan 2016
Published on 18 May 2017 By European Manual of Medicine: Coloproctology In Genetics
The two main inherited colorectal cancer syndromes are familial adenomatous polyposis (FAP) and Lynch syndrome (hereditary nonpolyposis colorectal cancer [HNPCC]), which account for less than 1 % and 3 % of colorectal cancers, respectively. FAP is characterized by the occurrence of multiple colorectal adenomas that often start to develop during the teenage years. A germ-line mutation in the APC gene located on chromosome 5 is found in about 85 % of patients with this phenotype. Without prophylactic surgery, nearly all will develop colorectal cancer. Surgery, including restorative proctocolectomy or total colectomy with ileorectal anastomosis, has greatly reduced the death rate from colorectal cancer, and now prognosis is dependent on desmoid tumors and duodenal polyposis.
HNPCC syndrome is more complex than FAP because more genes are involved, penetrance is less complete, and expression varies more. The recommendation is to try to determine the microsatellite instability (MSI) phenotype to test patients showing an MSI. Screening guidelines are well defined. Surgical management of HNPCC using segmental versus total colectomy is still debated.
A third syndrome, the MYH-associated polyposis syndrome, related to germ-line biallelic mutation of the human MUTYH gene, is an autosomal-recessive colon cancer syndrome. Other syndromes such as Peutz Jeghers syndrome, juvenile polyposis, and hyperplastic polyposis are seen less frequently.
Published on 13 November 2017 By ESCP Secretariat In Genetics
ESCP/EAES Symposium - Gabriela Möslein (Germany) at ESCP Berlin 2017
ESCP/EAES Symposium - Francesco Bianco (Italy) at ESCP Berlin 2017
ESCP Guidelines Update - Gabriela Möslein (Germany) at ESCP Berlin 2017
Published on 19 October 2018 By ESCP Secretariat In Genetics
Symposium - Matthias Kloor (Germany) at ESCP Nice 2018
Symposium - John Burn (UK) at ESCP Nice 2018
Symposium - Toni Seppälä (Finland) at ESCP Nice 2018
Published on 04 November 2019 By ESCP Secretariat In Genetics
Educational session - Gabriela Möslein (Germany) at ESCP Vienna 2019
ESCP/EHTG Symposium - Julian Sampson (UK) at ESCP Vienna 2019
ESCP/EHTG Symposium - Sanne ten Broeke (The Netherlands) at ESCP Vienna 2019
ESCP/EHTG Symposium - Magnus von Knebel Doeberitz (Germany) at ESCP Vienna 2019
Published on 23 September 2020 By ESCP Secretariat In Genetics
Symposium - Nick West (UK) at ESCP Virtually Vilnius 2020
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